Pharmacodynamic and pharmacokinetic properties of the novel antidepressant vortioxetine

Emmanouela Basgiouraki, Georgios Papazisis, Athanassios Apostolidis, Antonis Goulas


Vortioxetine is a novel antidepressant which exhibits multi modal activity; in addition to inhibiting the serotonin transporter (SERT) it interacts directly with various types of 5-HT receptors and is thus classified as a serotonin modulator and stimulator (SMS). This is a short update of recent findings concerning vortioxetine’s pharmacodynamics, pharmacokinetics and clinical use.


vortioxetine, antidepressant, pharmacodymamics, pharmacokinetics, clinical use

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