The genetic basis of cleft lip and cleft palate

Christos Veros, Zafiroula Iakovidou-Kritsi


Cleft lip and cleft palate (CLP) together or as isolated incidents constitute a large proportion of orofacial deformities which are observed during birth. It is a medical condition widely researched in the scientific community primarily because of health effects but also social effects on the everyday life of the affected children. There is wide speculation and much scientific data about the genes which are implicated on its genesis. CLP can be a clinical feature in many syndromes, but they can also be observed as isolated incidents in cases considered as non syndromic. Especially in non syndromic forms genetic heterogeneity and the differences among studied populations provide us with sometimes conflicting results about the implicated genes. It is also widely accepted that CLP is a multifactorial medical condition and in its pathogenesis, environmental factors also play a crucial role.


cleft, lip, palate, genetics

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