Biological factors of inflammation and methods of their detection

Theodoros Karampatakis, Dorothea Kapoukranidou

Abstract


Inflammation is a complicated process occurring after a harmful stimuli or infection. During inflammation a large number of biochemical reactions and pathophysiological changes take place. These procedures are all induced by active biological compounds called mediators or chemokines. These molecules are derived from plasma and cells and are capable of performing the appropriate changes both on the endothelium and cells during the inflammatory process. Moreover, some of them have the ability to interact with each other. Today there are different methods to detect and quantitate these compounds. These techniques keep on evolving and improving. Which one is the most suitable depends on the researcher’s scientific aim. A standardized protocol was created in order to make MRU feasible in everyday use, based on protocols suggested by other researchers. Both T1 and T2 weighted images were obtained using the following sequences: 2D Τ2-weighted fat saturation, 3D single shot fast spin-echo (SSFSE/RARE), 2D Radial SSFSE and T1-weighted gradient LAVA (3D SPGR). In 16 out of the 21 cases the MRU images and data agreed with the previous diagnosis based on radionuclide and ultrasound studies. In 5 cases MRU provided additional information, altering or even overruling the previous diagnosis. These 5 cases are presented in this article.


Keywords


Inflammation, Mediators, Chemokines, Biological determination

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